cell Genetic organization of the nucleusbiology

The nucleus » Genetic organization of the nucleus » The structure of DNA

DNA molecule[Credits : Encyclopædia Britannica, Inc.]Several features are common to the genetic structure of most organisms. First is the double-stranded DNA. Each strand of this molecule is a series of nucleotides, and each nucleotide is composed of a sugar-phosphate compound attached to one of four nitrogen-containing bases. The sugar-phosphate compounds link together to form the backbone of the strand. Each of the bases strung along the backbone is chemically attracted to a corresponding base on the parallel strand of the DNA molecule. This base pairing joins the two strands of the molecule much as rungs join the two sides of a ladder, and the chemical bonding of the base pairs twists the doubled strands into a spiral, or helical, shape.

The four nucleotide bases are adenine, cytosine, guanine, and thymine. DNA is composed of millions of these bases strung in an apparently limitless variety of sequences. It is in the sequence of bases that the genetic information is contained, each sequence determining the sequence of amino acids to be connected into proteins. A nucleotide sequence sufficient to encode one protein is called a gene. Genes are interspersed along the DNA molecule with other sequences that do not encode proteins. Some of these so-called untranslated regions regulate the activity of the adjacent genes, for example, by marking the points at which enzymes begin and cease transcribing DNA into RNA (see below Genetic expression through RNA).

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