human eye Anatomical basis; the retinal mosaicanatomy

From an anatomical point of view one may expect the limit to resolving power to be imposed by the “grain” of the retinal mosaic in the same way that the size of the grains in a photographic emulsion imposes a limit to the accuracy with which detail may be photographed. Two white lines on a black ground, for example, could not be appreciated as distinct if their images fell on the same or adjacent sets of receptors. If a set of receptors intervened between the stimulated ones, there would be a basis for discrimination because the message sent to the central nervous system could be that two rows of receptors, separated by an unstimulated row, were sending messages to their bipolar cells. Thus, the limit to resolution, on this basis, should be the diameter of a foveal cone, or rather the angle subtended by this at the nodal point of the eye; this is about 30 seconds of arc and, in fact, corresponds with the best visual acuity attainable. If this grain of the retinal mosaic is to be the basis of resolution, however, one must postulate, in addition, a nervous mechanism that will transmit accurately the events taking place in the individual receptors, in this case the foveal cones; i.e., there must be a one-to-one relationship between cones, bipolar cells, ganglion cells, and lateral geniculate cells so that what is called the local sign of the impulses from a given foveal cone may be obtained. It must be appreciated that restriction on convergence (or its reverse, spread) of messages may be achieved by inhibition; the anatomical connections may be there, but they may be made functionally inoperative by inhibition exerted by other neurons; thus, the horizontal and amacrine cells might well exert a restraining influence on certain junctions, thereby reducing the spread, or convergence, of messages, and it seems likely that the improvement in foveal visual acuity from one to two, brought about by increased luminance of the target and its surroundings, is achieved by an increase in inhibition that tends to make transmission one-to-one in the fovea.

It must be appreciated that true one-to-one connections in the retina do not exist; a cone, although making an exclusive type of synapse with a midget bipolar, may also make a less exclusive contact with a flat bipolar cell; furthermore, midget bipolars and cones are connected laterally by amacrine and horizontal cells so that it is most unlikely that a given optic nerve fibre carries messages from only a single cone. The one-to-one relationship may in fact exist under certain conditions, but that is because pathways from other receptors have been blocked or occluded by inhibitory processes that keep the line clear for a given cone.

The low visual acuity obtained in night, or rod, vision is now understandable. It has been pointed out that a high sensitivity to light is achieved by the convergence of rods on the higher neurons to allow spatial summation, and it is this convergence that interferes with the resolution of detail. If hundreds of rods converge on a single bipolar cell and if many bipolar cells converge on a single ganglion cell, it is understandable that the unit responsible for resolution may be very large and thus that the visual acuity is very small.