hybridomabiology

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Aspects of this topic are discussed in the following places at Britannica.

Assorted References

  • immunogenetics ( in genetics, human: The genetics of antibody formation )

    ...one antibody in abundance. Another method of obtaining large amounts of a specific antibody is by fusing a B lymphocyte with a rapidly growing cancer cell. The resultant hybrid cell, known as a hybridoma, multiplies rapidly in culture. Since the antibodies obtained from hybridomas are produced by clones derived from a single lymphocyte, they are called monoclonal antibodies.

  • production of monoclonal antibodies ( in monoclonal antibody: Hybridoma )

    ...results in a remarkable hybrid cell that produces the antibody made by its B-cell component but retains the capacity of its myeloma component to multiply indefinitely. Such a hybrid cell is called a hybridoma.

  • work of Milstein ( in Milstein, César )

    ...(see figure). The procedure involves fusing long-lived myeloma cells that do not produce antibodies with short-lived plasma cells that produce a specific antibody. The resulting hybrid cells, called hybridomas, combine the longevity of the myeloma cell with the ability to produce a specific antibody and so are able to produce potentially unlimited amounts of the desired antibody. Monoclonal...

Citations

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"hybridoma." Encyclopædia Britannica. 2009. Encyclopædia Britannica Online. 09 Jan. 2009 <http://www.britannica.com/EBchecked/topic/278044/hybridoma>.

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hybridoma. (2009). In Encyclopædia Britannica. Retrieved January 09, 2009, from Encyclopædia Britannica Online: http://www.britannica.com/EBchecked/topic/278044/hybridoma

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